Megamind, now known as Oliver Furry Megafowl Hansen (T.J. Miller) and his friends, Furry Artemis Chum-mania Sparky (James Corden) and Ren Keiko-mel Walker-Yamai (Awkwafina) have to face off against a group of superheroes (all portrayed by Shade except for Smurfette who is portrayed as Rihhana) known as the Hero Syndicate, keeping Oliver Furry Megafowl Hansen from taking over the World!